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ea0037gp.17.03 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Insulin-induced hypoglycaemia decreases IGF1 bioactivity in humans: a missing link to increased mortality in diabetic patients?

Sarem Zeinab , Assefa Biruhalem , Weickert Martin O , Adamidou Aikatarini , Frystyk Jan , Mohlig Matthias , Lieske Stefanie , Birkenfeld Andreas L , Pfeiffer A.F.H , Spranger Joachim , Arafat Ayman M

Background: The mechanisms underlying the association between severe hypoglycaemia and increased cardiovascular mortality among patients with diabetes mellitus are not fully understood. Our aim was to evaluate changes in GH/IGF1 axis during insulin-induced hypoglycaemia, as a possible link.Methods: Twenty-five healthy subjects, 12 obese participants (OP; 6/ 6; 34.4±1.7 kg/m2), and 13 healthy lean participants (LP; 6/ 7; 21.7±0.6 kg/m...

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Insulin-induced hypoglycaemia decreases IGF1 bioactivity in humans: a missing link to increased mortality in diabetic patients?

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